Thumbs up for inactivation
Article Abstract:
An unusual mechanism by which Ras-family proteins can be inactivated is revealed through new structural information. The structure reveals the molecular mechanism by which the GTPase-activating protein (GAP) induces guanine nucleotide triphosphate (GTP) hydrolysis and why cancer-causing mutations in Ras render the protein incapable of being inactivated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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A receptor unlocked
Article Abstract:
The structure and the biological functions of the G-protein-coupled receptors (GPCRs) that govern several biological functions are discussed. The G proteins are found to control various processes, including metabolic activity and cell movement.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Proton-sensing G-protein-coupled receptors
Article Abstract:
Ovarian cancer G-protein-coupled receptor 1 (OGR1), previously described as a receptor for sphingosylphosphorylcholine, acts as a proton-sensing receptor stimulating inositol phosphate formation is shown.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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