Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Article Abstract:
The ADP-ribosyltransferase activity of yeast Sir2, a heterochromatin element that silences transcription at silent mating loci, telomeres and the ribosomal DNA, may play a role in DNA repair. This hypothesis is supported by research indicating that the ADP-ribosylation of histones takes place when cells are treated with DNA damaging agents and that antibodies against mono-ADP-ribose react with mammalian nuclei only when cells are treated with DNA-damaging agents. The nicotinamide adenine dinucleotide requirement of Sir2 for deacetylation indicates that this protein could be a sensor of the energy or oxidation state of cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Sirtuins as potential targets for metabolic syndrome
Article Abstract:
The research in the field of ageing, which might help to identify important mediators of calorie restriction offering the hope of new drugs to improve healthspan is explored. Findings reveal that sirtuins and other important metabolic pathways that affect calorie restriction might serve as entry points for drugs to treat ageing, insulin insensitivity, obesity and other symptoms associated with metabolic syndrome.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Article Abstract:
Research is presented concerning the mutations of Caenorhabditis elegans which reduce the effectiveness of an insulin-like receptor and extend the lifespan of the adults. The influence of the sir-2 gene is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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