Wee beasties

Article Abstract:

Paul Nurse describes his experience in his scientific life that involved a group of individuals at Murdoch Mitchison's laboratory in the zoology department at the University of Edinburgh working mainly with the fission yeast Schizosaccharomyces pombe in the cell-division cycle. From this experience he learnt the importance of spending time trying to understand the real biological significance of observations made on cells and organisms before undertaking detailed investigations of the molecular mechanisms involved.

United States, Gene mutations, Gene mutation, Saccharomyces, Yeast fungi, Yeasts (Fungi)

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A network-based analysis of systemic inflammation in humans

Article Abstract:

A structured network knowledge-base approach is presented to analyze genome-wide transcriptional responses in the context to known functional inter-relationships among proteins, small molecules and phenotypes. Analysis reveals that the human blood leukocyte response to acute systemic inflammation includes the transient dysregulation of leukocyte bioenergetics and modulation of translational machinery.

Analysis, Genetic aspects, Human beings, Humans, Leukocytes, White blood cells, Man, DNA microarrays

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