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Caspase-1 builds a new barrier to infection

Article Abstract:

A new strategy for host defense in which caspase-1 promotes cell survival by activating a pathway that repairs the cellular damage inflicted by pore forming toxins is reported. Upon activation, caspase-1 processes the pro-inflammatory cytokines IL-1[beta] and IL-18, leading to their secretion, which contributes to the innate immune response and host defense.

Author: Saleh, Maya

Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006

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The inflammasome: First line of the immune response to cell stress

Article Abstract:

NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. New insights into the regulation of caspase-1 activity in the inflammatory response are discussed.

Author: Flavell, Richard A., Ogura, Yasunori, Sutterwala, Fayyaz S.

Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006

United States, Protein research

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Subjects list: Research, Cytokines, Apoptosis

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