A dermal HOX transcriptional program regulates site-specific epidermal fate
Article Abstract:
A study is done to show that expression of a distal-specific gene, HOCA13, is required and the transcriptional targets are sufficient to maintain epidermal inductive properties of distal fibroblasts. It is concluded that maintenance of appropriate HOX transcriptional program in adult fibroblasts serve as a source of positional memory to differentially pattern the epithelia during homeostasis and regeneration.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2008
User Contributions:
Comment about this article or add new information about this topic:
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
Article Abstract:
The promotion of EMT (Epithelial-to-mesenchymal transition) during both cardiac development and oncogenic transformation by Notch activity is demonstrated. Notch is expressed in an embryonic region where EMT occurs, suggesting an intimate and fundamental role for Notch that may be reactivated during tumor metastasis.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors
Article Abstract:
The data from mammalian studies is implemented for analysis on how epithelial polarity and proliferation can be linked and how disruption of polarity can promote cancer. The role of the fly 'neoplastic tumor suppressor genes' in controlling cell polarity and proliferation is reviewed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Churchill, a zinc finger transcriptional activator regulates the transition between gasrulation and neurulation
- Abstracts: How the sperm lost its tail: The evolution of aflagellate sperm. Darwinian aesthetics: sexual selection and the biology of beauty
- Abstracts: PIAS proteins and transcriptional regulation-more than just two SUMO E3 ligases? Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA
- Abstracts: Acetylation in histone H3 globular domain regulates gene expression in yeast. Discoveries of nicotinamide riboside as a nutrient and conserved Nrk genes establish a preiss-handler independent route o NAD (super +) in fungi and humans
- Abstracts: Traversing the conceptual divide between biological and statistical epistasis: Systems biology and a more modern synthesis