PIAS proteins and transcriptional regulation-more than just two SUMO E3 ligases?

Article Abstract:

PIAS protein action can either be activating or repressive, although their mechanism of action apparently differs depending on the target gene or interacting transcriptional regulator. The frequent association of PIAS proteins with SUMO-modified proteins has given rise to the suggestion that PIAS proteins might play an analogous role as E3 ligases for the SUMO modification pathway.

Genetic transcription, Transcription (Genetics)

---

Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complex

Article Abstract:

The cooperative binding of Pleiohomeotic (PHO) and a multiprotein Polycomb core complex (PCC) with Polycomb response elements (PREs) is discussed. The functioning of PHO sites and PCC-binding elements (PBEs) as an integrated DNA platform result in the synergistic assembly of a repressive PHO/PCC complex.

Epigenetic inheritance

---

Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA

Article Abstract:

Purified proteins and complexes that are reconstituted from recombinant are used to characterize the effects of GAGA and Zeste proteins on Polycomb group (PcG) function using a defined in vitro system. Distinct means are used by Zeste and GAGA factor to increase repression mediated by PRC1.

Nucleotide sequence, Base sequence

Similar abstracts:

• Abstracts: The robustness of the transcriptional response to alterations in morphogenetic gradients
• Abstracts: G proteins are required for spatial orientation of early cell cleavages in C. elegans embryos. The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus
• Abstracts: Paralogs and mutational robustness linked through transcriptional reprogramming. Alternative splicing and evolution
• Abstracts: Dynamic cross-talk between cells and the extracellular matrix in the testis. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology
• Abstracts: Inbreeding depression in self-incompatible and self-compatible populations of Leavenworthia alabamica. Overdominant lethals as part of the conifer embryo lethal system

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.