Traversing the conceptual divide between biological and statistical epistasis: Systems biology and a more modern synthesis
Article Abstract:
A study reviewed definitions and examples of biological and statistical epistasis and explored the relation between the two. The result gives necessary information regarding when the statistical evidence of epistasis in human populations imply underlying bimolecular interactions in the etiology of disease and also regarding when the biological interactions produce patterns of statistical epistasis.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
The importance of stress and genetic variation in human aggression
Article Abstract:
Reaction to stress seems to be a significant factor in precipitating aggressive episodes and individuals may vary in their ability to cope with stressful environments depending on their genetic composition. Common alleles of some serotonin pathway genes, including those involved in its degradation or its reuptake into pre-synaptic neurons, are shown to confer functional variation.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
The use of animal models in the study of the complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?
Article Abstract:
The controlling genetic background in animal studies can produce more consistent results and hence it is suggested that the failure to replicate human findings in the same diseases is due to the variation in interacting genes. Such contrasting nature of findings from different study designs shows the importance of non-additive genetic effects on human disease.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Maximum dive depths of the Peruvian diving-petrel. Reproductive biology and vocalizations of the horned guan Oreophasis derbianus in Mexico
- Abstracts: Characterization of the chemical and antimicrobial properties of piscicolin 126, a bacteriocin produced by Carnobacterium piscicola JG126
- Abstracts: The robustness of the transcriptional response to alterations in morphogenetic gradients
- Abstracts: HTP1 dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis
- Abstracts: The effect of non-additive genetic interactions on selection in multi-locus genetic models. Allelic diversity of S-RNase at the self-incompatibility locus in natural flowering cherry populations (Prunus lannesiana var. speciosa)