Alleviation of glucose repression of maltose metabolism by MIG1 disruption in Saccharomyces cerevisiae

Article Abstract:

Glucose repression is partly alleviated by MIG1 gene disruption in the haploid strain of Saccharomyces cerevisiae. This implies that maltose metabolism begins at higher glucose concentrations in this strain than in the corresponding wild-type strain. The wild-type strain shows less rigorous glucose control of maltose metabolism than the corresponding haploid strain. This is attributed to a less rigorous catabolite inactivation of maltose permease which affects the uptake of maltose. MIG1 disruption induces changes in the pattern of secreted metabolites and the specific growth rate.

Physiological aspects, Gene mutations, Gene mutation, Glucose metabolism

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Improvement of galactose uptake in Saccharomyces cerevisiae through overexpression of phosphoglucomutase: Example of transcript analysis as a tool in inverse metabolic engineering

Article Abstract:

Information about the global transcriptional response to metabolic engineering of galactose metabolism in yeast (the GAL gene) regulatory network is obtained through genome-wide transcript analysis of a reference strain and two recombinant Saccharomyces cerevisiae strains with different rates of galactose uptake. Results reveal that overexpression of phosphoglucomutase results in increased flux through the Leloir pathway.

Science & research, Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Genetic aspects, Genetic research, Brewer's yeast, Saccharomyces cerevisiae, Phosphoglucomutase, Galactose

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Metabolic engineering of Saccharomyces cerevisiae

Article Abstract:

Saccharomyces cerevisiae can be metabolically engineered to produce specific substances. Researchers continue to extend substrate range, improve productivity and yields, eliminate byproduct formation, and extend the types or substances produced.

Microbial genetic engineering

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