Anti-neural-inhibition: a conserved mechanism for neural induction
Article Abstract:
Early neurogenesis in the neuroectoderm of Drosophila was characterized by the division of embryonic cells into the ventral, laterat and dorsal mesoderm, neuroectoderm and nonneural ectoderm. The differentiation of the embryonic cells was also dependent and regulated by the expression of several transcription factors inculding the decapentaplegic, zerknullt and tolloid genes. Furthermore, the maintainance of initial cell division for the determination of the neuroectodermal position was dependent on the expression of specific zygotic genes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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%% trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry
Article Abstract:
Mammalian genes related to the Drosophila trp gene encode proteins that form the subunits of the channels required for agonist-activated capacitative Ca2+ entry (CCE) into mammalian cells. In COS cells, the expression of two full-length cDNA's encoding the human trp homologs, Htrp1 and Htrp3, increase CCE by 75% and 230%, respectively. Ca2+ influx due to endogenous COS cell CCE channels is more sensitive to suppression by La3+ and Ni2+ than that mediated by Htrp3. The expression of the genes in the antisense orientation inhibits CCE.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Why the rat-1 fibroblast should replace the SCN as the in vitro model of choice
Article Abstract:
The suprachiasmatic nucleus (SCN) has been regarded as the controller of the circadian rhythm among mammals. However, recent studies have shown that rat fibroblasts kept in culture and subcultures for 25 years exhibit rhythmicity in messenger RNA synthesis after serum shock. The rhythm has a period of 22.5 hours and is maintained for two to three days after the serum shock. The control of the mammalian circadian rhythm may not rest solely on the SCN.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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