A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord
Article Abstract:
Roof plates and TGFbeta-related proteins were studied to determine its function in stimulating and patterning interneurons in the dorsal spinal cord. Results show that two interneurons called D1 and D2 were produced near the roof plate and its production was induced by the the TGFbeta family. Thus, it is derived that neurons are patterned due to the signals induced by the TGFbeta-related proteins in the dorsal spinal cord and later multiplied by the roof plate.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation
Article Abstract:
It is uncertain which isoforms of CREB, CREM or ATF1 are expressed in neurons undergoing long-term synaptic changes. A single Aplysia CREB1 gene has been found to be homologous to both mammalian CREB and CREM. CREB1a is a transcriptional activator, required for long term facilitation, while CREB1b represses long term facilitation. CREB1 is found to encode a critical regulatory unit, that converts short to long-term synaptic changes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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