C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
Article Abstract:
Two Caenorhabditis elegans 14-3-3 proteins were identified as SIR-2.1 binding partners and it is demonstrated that 14-3-3 genes are required for the life-span extension conferred by extra copies of sir-2.1. Findings suggest the existence of a stress-dependent pathway in which SIR-2.1 and 14-3-3 may act in parallel to the insulin-like pathway to regulate DAF-16 and extend life span.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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The KEOPS complex: A rosetta stone for telomere regulation
Article Abstract:
A study is conducted to identify a new complex, called KEOPS, which promotes both telomere uncapping and elongation. The defect telomere length that is observed in KEOPS mutants is due to a defect in resection, which leads to reduced binging of Cdc13 and Rpa1, and ultimately reduced recruitment of Est1 and Est2.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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