Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor

Article Abstract:

A vertebrate osmoreceptor candidate has been identified in the vanilloid receptor-related osmotically activated channel (VR-OAC). Researchers cloned cDNAs encoding the VR-OAC from rats, mice, humans and chickens. A candidate-gene approach was based on genes encoding members of the TRP superfamily of ion channels. In the central nervous system, the channel is expressed in neurons of the circumventricular organs. These are neurosensory cells that respond to systemic osmotic pressure. The channel is in other neurosensory cells as well.

Fluid-electrolyte balance, Central nervous system, Cell receptors, Ion channels, Osmoregulation, Neural stimulation

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Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca(super.2+) channels

Article Abstract:

Congenital deafness and sinoatrial node dysfunction are discussed relative to mice that do not have class D L-type Ca(super.2+) channels (D-LTCCs). Viable D-LTCC-deficient mice with no major disturbances of glucose metabolism were generated and studied. They were deaf because they lacked L-type currents in cochlear inner hair cells and degeneration of outer and inner hair cells.

Italy, Austria, Calcium channels, Deafness

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The structure of the ligand-binding domain of neurexin I beta: regulation of LNS domain function by alternative splicing

Article Abstract:

The structure of the ligand-binding domain of neurexin I-beta is discussed. A study has been carried out in an effort to find information about the structural basis of the function of LNS domains and their regulation by alternative splicing through structure determination of neurexin Ibeta.

Brain, Homology (Biology), Protein folding, Ligand binding (Biochemistry), Proteoglycans, Nerve proteins, Nerve tissue proteins

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