Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development
Article Abstract:
Three proteins, namely, Hedgehog (Hh), Wingless (Wg) and Decapentaplegic (Dpp), are responsible for the growth and patterning of the Drosophila leg. Hh, which is secreted in the posterior cells, induces the dorsal anterior cells to secrete Dpp and the ventral anterior cells to secrete Wg. The complementary patterns of dpp and wg expression are studied. Results indicate that the patterns are maintained by mutual repression, which is essential for normal axial patterning.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Protein kinase A and hedgehog signaling in Drosophila limb development
Article Abstract:
A study of the role of protein kinase A (PKA) and hedgehog (hh) signaling in limb development in Drosophila reveals that PKA inhibits irregular wingless (wg) and decapentaplegic (dpp) expression during limb development. hh removes the PKA-induced block, promoting wg and dpp expression. Removal of PKA activity in anterior cells results in the expression of wg and dpp by these cells, leading to the rearrangement of the surrounding wild-type tissue.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Dual roles for patched in sequestering and transducing hedgehog
Article Abstract:
Genetic evidence supporting the role of the Patched (Ptc) protein in signal transduction of the Hedgehog family are presented. Using in vivo assays, it is shown that Ptc binds Hh which leads to alterations in cellular behavior. The results also reveal that Ptc inhibits the spread of Hh from the P into the A compartment cells when present at excessively high amounts. A model illustrating Ptc activities is presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Nitric oxide regulates cell proliferation during Drosophila development. Regulation of multimers via truncated isoforms: a novel mechanism to control nitric-oxide signaling
- Abstracts: The RNA silencing endonuclease argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster. Lozenge directly activates Argos and klumpfuss to regulate programmed cell death
- Abstracts: Noelins modulate the timing of neuronal differentiation during development. Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation
- Abstracts: The roles of nitric oxide in murine cardiovascular development. Asymmetrization of first cleavage by transient disassembly of one spindle pole aster in the leech Helobdella robusta
- Abstracts: Molecular characterization and expression patterns of a B-type nuclear lamin during sea urchin embryogenesis. Assembly of spermatid acrosome depends on microtubule organization during mammalian spermiogenesis