Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo

Article Abstract:

Remodeling of chromatin through histone acetylation seems to have a fundamental role in gene regulation. Alanine-scan mutagenesis through the already-identified histone acetyltransferase (HAT) domain has been carried out. Several substitution mutations that got rid of the ability of Gcn5 to potentiate transcriptional activation in vivo have been identified. Each mutation was essential for nucleosomal and free histone acetylation by Gcn5 functioning in native yeast HAT complexes Ada and SAGA. It seems acetylation is needed for gene regulation by Gcn5 in vivo. Nucleosomal histones appear to be among the physiological acetylation substrates by Gcn5.

Genetic regulation

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Acetylation of histones and transcription-related factors

Article Abstract:

Research points out that acetylation of histones is closely connected with the transcriptional regulation as revealed by nuclear histone acetyltransferases and their transcription-related substrates. Additionally, discovery of a nuclear transcriptional adaptor protein exhibiting histone acetyltransferase activity indicate that histone acetylation is an inherent characteristic of transcription.

Physiological aspects, Cell receptors, Cell nuclei, Cell nucleus

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Natural biology of polyomavirus middle T antigen

Article Abstract:

This review discusses mouse polyomavirus transformation and their natural life cycle in vertebrate species with reference to the role played by the middle T antigen in the viral replication and transcription, apoptosis, signal transduction pathways, development of transgenic mice, and mechanistic aspects of tumor development.

Models, Genetic aspects, Cell death, Polyoma virus, Polyomavirus, Cellular signal transduction, Carcinogenesis, Genetically modified mice, Genetic transformation, Viral antigens

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