Heterotrimeric G proteins: organizers of transmembrane signals
Article Abstract:
G proteins with different subunits form receptors for physical or chemical signals in cells. The alpha- and beta-gamma-subunits modulate several cellular transduction effectors, the distribution of regulation being specific to the effector subtype. The alpha subunit is formed by two domains, a GTPase domain with the guanine nucleotide-, receptor-, beta-gamma- and effector-binding pockets, and a helical domain. The beta-subunit has a conserved N terminal and seven repeat units of 43 amino acids each.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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RIC-8 is required for GPR-1/2-dependent G alpha function during asymmetric division of C. elegans embroys
Article Abstract:
The evolutionary conserved protein RIC-8 is needed for proper asymmetric division of one-cell stage C. A mechanism has been developed in which RIC-8 favors generation of G alpha free from G beta gamma.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans
Article Abstract:
Heterotrimeric G proteins are known to promote microtubule forces that position mitotic spindles. RIC-8 stimulates GTP binding by G alpha (sub o).
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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