Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1

Article Abstract:

The bHLH-PAS transcription factor SIM1, which is expressed during development of the hypothalamic-pituitary axis, is necessary for development of neuroendocrine lineages. SIM1 is expressed in three hypothalamic nuclei, the supraoptic nucleus (SON), the anterior periventricular nucleus (aPV), the paraventricular nucleus (PVN). SIM1 acts upstream to maintain Brn2 expression. The expression then directs terminal differentiation of specific neuroendocrine lineages in the PVN/SON. There is evidence that in development of Sim1 mutant hypothalamus, the prospective PVN/SON region does not express Brn2. Mice with a null allele of Sim1 were produced to study Sim1 function in the hypothalamus. The SON and PVN of the mice are hypocellular. At the final stages of their differentiation, SIM1 controls the development of five types of secretory neurons.

Hormones, Hypothalamus, Hypothalamic-pituitary-adrenal axis, Neurohormones

---

The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor

Article Abstract:

Tat-Sf1, an HIV-1 Tat cellular coactivator protein, is a transcription elongation factor of the general sort. It stimulates transcription elongation from the HIV-1 long terminal repeat (LTR) strongly and specifically. It provides a very useful in vitro model system to study the process. Protein-affinity chromatography has been used to identify cellular factors with important roles in transcription elongation. Results indicate that an ATP-inactivatable general elongation factor (AIEF) necessary for Tat-SF1 activity, and for which Tat can substitute in a functional way, exists.

HIV (Viruses), HIV

---

Similar abstracts:

• Abstracts: Nucleosome positioning by the winged helix transcription factor HNF3. Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin-remodelers in DNA double-strand break repair
• Abstracts: The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system
• Abstracts: Quantification of bias related to the extraction of DNA directly from soils. Phylogenetic analysis of nonthermophilic members of the kingdom Crenarchaeota and their diversity and abundance in soils
• Abstracts: Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection
• Abstracts: The Cdc7 protein kinase is required for origin firing during S phase. S-phase specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.