Does apoptosis-inducing factor (AIF) have both life and death functions in cells?

Article Abstract:

The ability of mitochondrial apoptosis-inducing factor (AIF) to suppress cytoplasmic stress granule formation and to promote the tumorigenic growth of cancer cells is analyzed. The main function of the AIF is found to support energy production in both normal and transformed cell physiology, whereas nuclear-translocated AIF might contribute to stress-induced or pathological cell death in certain scenarios.

Mitochondrial DNA, Cancer cells, Phosphorylation

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Cellular toxicity of oxycholesterols

Article Abstract:

Oxycholesterols (OS) are formed from cholesterol or its immediate precursors by enzymatic or free radical action in vivo or might be derived from food. A review of the most-important aspects of OS cytotoxic activities, in particular its influence on HMG-CoA reductase activity, antiproliferative action and apoptosis based on experimental results is presented.

Poland, Cholesterol, Oxidation-reduction reaction, Oxidation-reduction reactions, Chemical properties, Toxicity

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Apoptosis initiated by dependence receptors: a new paradigm for cell death?

Article Abstract:

A distinct group of receptors including DCC, UNC5, RET and PTC1 acts as dependence receptors and regulate neuronal cell survival by inducing apoptosis in the absence of cognate ligand. Dependence receptor initiated apoptosis that controls removal of specific cells during neural development and elimination of malignant cells is discussed.

United States, Ligand binding (Biochemistry), Cytokines

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