Epigenetic deregulation of imprinting in congenital diseases of aberrant growth
Article Abstract:
Human chromosomes 11p15 comprises two imprinted domains, which are important in the control fetal and postnatal growth which was studied by imprinting epigenetically deregulated in Silver-Russell Syndrome (SRS), a congenital disease of growth retardation and asymmetry. It showed that fetal and postnatal growth is epigenetically controlled by different imprinting control regions (ICRs) at 11p15 and other chromosomal regions.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2006
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MEDEA takes control of its own imprinting
Article Abstract:
The activation of the maternal copy of the imprinted MEDEA Polycomb gene by DEMETER is discussed. It is demonstrated that this activation involves DNA demethylation of MEDEA by DMETER, which shows that silencing of the paternal MEDEA allele is independent of DNA methylation, and is controlled by maternal expression of MEDEA itself.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation
Article Abstract:
DNA glycosylase DEMETER (DME) establishes endosperm maternal-allele-specific hypomethylation at the MEDEA (MEA) gene. DME removes 5-methylcytosine for activating the maternal allele and thus establishes MEA imprinting.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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