FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death
Article Abstract:
Research has been conducted on the common cause of sudden cardiac death, arrhythmias. The authors suggest that ryanodine receptor channels can trigger fatal cardial arrhythmias explaining catecholaminergic polymorphic venticular tachycardia.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
Italy, United States, Analysis, Causes of, Physiological aspects, Genetic aspects, Calcium channels, Genetic polymorphisms, Cell research, Cytological research, Cardiac arrest, Heart muscle, Myocardium, Ventricular tachycardia, Catecholamines, Binding proteins, Sudden cardiac death
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias
Article Abstract:
Phosphodiesterases (PDEs) regulate the local concentration of 3',5' cyclic adenosine monophosphate (cAMP) within cells. It is shown that PDE4D gene inactivation in mice results in a progressive cardiomyopathy, accelerated heart failure after myocardial infarction and cardiac arrhythmias.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Science & research, Research, Risk factors, Heart failure, Cyclic adenylic acid, Cyclic adenosine monophosphate, Phosphodiesterases
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Subjects list: Arrhythmia
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