Function of trigger factor and DnaK in multidomain protein folding: Increase in yield at the expense of folding speed
Article Abstract:
Trigger factor and DnaK protect nascent protein chains from misfolding and aggregation in E. coli cytosol. Studies show that trigger factor and DnaK improve the folding yield of proteins but delay folding process both in-vitro as well as in-vivo and this needs dynamic recruitment of additional trigger factor molecules to translating ribosomes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4 multiubiquitylation complex in C.elegans
Article Abstract:
The organization of the motor protein myosin into cell division, cell motility, vesicular traffic requires precise temporal and spatial control. A novel interaction between the myosin chaperone UNC-45 and the C.elegans orthologs of carboxyl terminus of Hsc 70-interacting protein is examined.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli
Article Abstract:
The Escherichia coli chaperonin GroEL and its cofactor GroES promote protein folding by sequestering nonnative polypeptides in a cage like structure. The contribution of this system to protein folding across the entire E. coli proteome is defined.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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