HFR1 is targeted by COP1 E3 ligase for post-translational proteolysis during phytochrome A signaling
Article Abstract:
The post-translational proteolysis during phytochrome A signaling is studied wherein HFR1, a basic helix-loop-helix (bHLH) transcription factor, is targeted by the COP1 (Constitutive Photomorphogenesis) ligase. The results suggest that the HFR1 is ubiquitinated by COP1 E3 ligase and marked for post-translational degradation during photomorphogenesis.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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Independent and interdependent functions of LAF1 and HFR1 in phytochrome A signaling
Article Abstract:
The role played by LAF1 and HFR1 in phytochrome A signaling is discussed. It is found that these two factors interact in vitro and invivo and one consequence of this interaction is an inhibition of their ubiquitination by the COP1 E3 ligase, leading to a post-translational stabilization of the factors.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease
Article Abstract:
The role of amylo-1,6-glucosidase,4-[alpha]-glucanotransferase (AGL) enzyme in the glycogen storage disorders of Lafora and Cori's disease is reported. Findings show that the ubiquitination of enzyme is found to play an important role in pathophysiology of these diseases.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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