In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects

Article Abstract:

Research reveals that continuous supply of the angiogenesis inhibitor thrombospondin 1 to fast-growing tumors leads to tumor resistance. Data indicate that this tumor resistance is brought about by the in vivo outgrowth of the tumor-cell variants, whose angiogenic factors counterbalance thrombospondin 1 inhibitory effect on neovascularization.

France, Statistical Data Included, Cancer research, Cancer, Neovascularization, Tumors

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Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression

Article Abstract:

The mutations of Pten wild type allele and H-ras are contained in the tumors, which display that H-ras is vigorous and the Pten is totally lost, both are mutually distinct incidences in the skin carcinomas. This information has significant impact in the formation of distinct therapeutic approaches for curing cancer.

Science & research, Development and progression, Mutation (Biology), Mutation, Skin cancer

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TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(sub)1 arrest

Article Abstract:

Research was conducted to demonstrate growth inhibition by TGF-beta in eukaryotic cells. Results show that cell cycle arrest occurs via inhibition of p70 S6 kinase by a complex formed between TGF-beta receptor and phosphatase-2A-Balpha subunit.

Cells (Biology), Cell cycle, Cells, Epidermal growth factor, Epidermal growth factors

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