PIKE: a nuclear GTPase that enhances P13kinase activity and is regulated by protein 4.1N

Article Abstract:

Results show that two-hybrid analysis reveals interactions of erythrocyte membrane cytoskeleton protein 4.1N, the nuclear mitotic apparatus protein, and nuclear GTPase that binds and activates nuclear P13Kinase. The protein involved in the above processes is called phosphoinositide kinase enhancer (PIKE).

Research, Enzymes, Yeast, Yeast (Food product), Protein kinases, Binding sites (Biochemistry), Active sites (Biochemistry), Neurology, Enzyme regulation

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Comprehensive analysis of photoreceptor gene expression and the identification of candidate retinal disease genes

Article Abstract:

Results reveal 264 retinal rod specific genes that are involved in human retinal diseases. Data identify 86 photoreceptor genes mapping on 37 different loci.

Genetic aspects, Retinal diseases, Gene expression, Photoreceptors

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Inositol pyrophosphatases mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P(sub)3 interactions

Article Abstract:

Research shows physiologic regulation of chemotaxis by diphosphoinositol pentakisphosphate mediated by its competition with pleckstrin homology domain-PtdIns(3,4,5)P(sub)3 in Dictyostelium. Data indicate that chemotaxis is mediated by membrane translocation of PH domain-containing proteins.

Cellular signal transduction, Biological transport, Chemotaxis, Inositol phosphates

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