Is there a functional link between gene interdigitation and multi-species conservation of synteny blocks?
Article Abstract:
The need to conserve long-range CRSs in cis with their target PCSs through evolution is proposed, in combination with gene interdigitation and co-regulation of many genes by individual CRSs, has contributed to the persistence of conserved synteny blocks between diverse species. Further, hypothesise the examination of the varying extents of synteny blocks between multiple species in combination with phylogenetic footprinting to find CRSs might provide important clues to the existence of crucial functional CRS-PCS linkages.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2004
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What tangled web: Barriers to rampant horizontal gene transfer
Article Abstract:
Natural barriers that protect modern genome populations from the inroads of rampant horizontal gene transfer (HGT) are identified. Two extreme modes of HGT, one based on the invasiveness of transgenic bacteria in very large populations of single cells with relatively small genomes and the other based on infectious mobile elements propagating in relatively small populations of multicellular organisms with relatively large genomes are explored.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2005
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Leptin leads hypothalamic feeding circuits in a new direction
Article Abstract:
The discovery of adipocyte-derived hormone, a mediator in a negative feedback loop that controls body adipostat has led to a rapid revolution in the understanding of neurobiological mechanisms regulating obesity. However, it is known to have a wide range of additional neuroendocrine, metabolic and behavioral functions in the CNS and periphery while leptin's first life was as an adipostat.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2004
User Contributions:
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