Linking colorectal cancer to Wnt signaling
Article Abstract:
The review examines the etiology of human colorectal cancer from the point of independent genetic deviations such as beta-catenin deregulation leading to malignancy in the gut epithelium, Adenomatous polyposis coli influencing tumor progression, and finally the central role of the Wnt siganaling pathway.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Wnt/[beta]-catenin signaling in development and disease
Article Abstract:
The roles of the canonical Wnt signaling pathway, which are activated by Wnt proteins, in development, tissue self-renewal and cancer are examined. Wnt signaling is involved in every aspect of embryonic development, where it controls homeostatic self-renewal in many adult tissues and somatic mutations are associated with cancer of the intestine and many other tissues.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic
Article Abstract:
The role of the lymphocyte enhancer binding factor 1 (LEF-1) in the regulatory feedback loop between Ultrabithorax (Ubx) and wingless (wg) in the wingless signaling pathway was investigated. The results confirmed the presence of a wg response sequence (WRS) in the visceral mesoderm enhancer from Ubx which was identified to be a binding site for mammalian LEF-1. It was also shown that LEF-1 can form a stable complex with arm protein on the Ubx WRS and that its function of enhancing transcription requires dpp signaling. Such findings indicate that LEF-1 coordinates and regulates the assembly of multiprotein enhancer complexes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development. Drosophila Brain Tumor is a translational repressor
- Abstracts: Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction. BH3-only proteins--essential initiators of apoptotic cell death
- Abstracts: Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. Signaling to chromatin through histone modifications
- Abstracts: Structural basis for the autoinhibition of c-Abl tyrosine kinase. Structural basis for the inhibition of caspase-3 by XIAP