Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo
Article Abstract:
A study was conducted to show that expression of BMP-4 affects the regulation of lateral or dorsal mesodermal and neural genes and leads to the formation of a diminished neural plate. Ectopic expression of BMP-4 inhibits the formation of the dorsal and lateral mesoderm, while elimination of BMP-4 reverses the effect and alters the phenotype in the early embryo. These results suggest that expression of BMP-4 can be controlled to achieve desired effects.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Defects in limb, craniofacial, and thymic development in Jagged2 mutnt mice
Article Abstract:
Jagged2 gene and Notch signaling, which is a intercellular signaling mechanism, play an important part in the limb, thymic and craniofacial development of mice. Mutant mice without a domain of the Jagged2 protein had fatal defects in craniofacial morphogenesis. The mice also had fusion in the limbs and modified thymic morphology.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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