LAG2, a gene that determines yeast longevity

Article Abstract:

The yeast Saccharomyces cerevisiae is used to examine the genetic basis of longevity. The yeast has a limited life span, and a number of genes which are differentially expressed during its life span are isolated. Its gene LAG2 has been singled out for its role in assuring longevity. Its deletion in a haploid strain led to a 50% decline in the mean and maximum life span. Overexpression, meanwhile, resulted in the extension of the yeast's mean and minimum life span by about 36% and 54%, respectively.

Analysis, Gene expression, Longevity

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Candida albicans SSD1 can suppress multiple mutations in Saccharomyces cerevisiae

Article Abstract:

Research was conducted to examine the hypothesis that Candida albicans SSD1 can suppress multiple mutations in Saccharomyces cerevisiae. A functional homologue of the SSD1 gene was isolated and characterized based on its capacity to restore viability at the restrictive temperature in a S cerevisiae swi4 ssd1-d strain. Results demonstrated a functional and structural relationship between the C albicans and S cerevisiae proteins which suggests a common molecular activity for the two proteins.

Research, Gene mutations, Gene mutation, Bacterial proteins, Candida albicans

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