Molecular mechanisms of muscle atrophy
Article Abstract:
Skeletal muscle atrophy, which can be defined as decrease in muscle mass has adverse consequences but molecular mechanisms that mediate the process of atrophy are not well defined. Studies show that the involvement of ubiquitin proteasome may be common to a range of atrophic stimuli and these findings will help in opening a range of options that can be used in alleviating the pain associated with muscle atrophy.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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The proteasome: Not just degrading anymore
Article Abstract:
The functions of the proteasome, which is a large multiprotein complex, playing a critical role in the degradation of ubiquitylated proteins, are studied. The studies reveal that the proteasome also plays an active role in multiple aspects of gene expression, including the recruitment of coactivation to promoters, the initiation of transcription, and elongation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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UPS shipping and handling
Article Abstract:
A brief review on the operation levels of the ubiquitin-proteasome system (UPS), a major route for regulated protein destruction in eukaryotic cells is presented. A report suggests the way in which several of the known players in the process might work together in guiding and delivering some substrates to their final destinations.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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