Mutational analyses of fs(1)Ya, an essential, developmentally regulated, nuclear envelope protein in Drosophila
Article Abstract:
The role of the fs(1)Ya (Young arrest) gene product (YA) in the nuclear envelope during early embryonic development in Drosophila was investigated. The phenotypes of four Ya gene mutant alleles were examined and the location of their molecular lesions determined by DNA sequencing and polymerase chain reactions. Ya mutants produced unfertilized eggs containing nuclei of different sizes and condensation states. The site of mutation was at lamin, which is localized at the periphery of the uncondensed nuclei. These results support that YA facilitates proper chromatin condensation by preventing the formation of a lamin-containing nuclear envelope.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1995
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Drosophila Notch receptor activity suppresses hairless function during adult external sensory organ development
Article Abstract:
The cellular basis by which mutations in the neurogenic Notch (N) locus of Drosophila suppress mechanosensory bristle development on the notum was examined. Their interaction with hairless (H), an antagonist of many neurogenic genes and which suppress the inhibition of the sensory organ precursor (SOP), was also investigated. The results showed that Notch gain-of-function alleles and activation of a Notch transgene enhances Notch receptor activity and produces H-like loss-of-function phenotypes by suppressing SOP cell specification.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1995
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Selection and maintenance of sexual identity in the Drosophila germline
Article Abstract:
A study was conducted to investigate the processes involved in sex determination in the germline of Drosophila. Both inductive and autonomous components of Drosophila were examined to determine how sexual identity is selected and maintained in the Drosophila germline. The results showed that female-specific expression of genes in the germline is dependent on the somatic signaling pathway.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1995
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