Phospholipase C-gamma1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
Article Abstract:
Platelet-derived growth factors (PDGF) associate with phospholipase C-gamma1 (PLC-gamma1), the Ras GTPase activating protein (RasGAP), phosphatidylinositol 3 kinase (P13K) and a 64-kd protein upon ligand-induced tyrosine phosphorylation. A PDGF receptor mutant which can not bind any factor and mutants which can only bind one of these factors were constructed to determine the role of these factors. Results showed that PLC-gamma1 and P13K are the downstream mediators that initiate DNA synthesis. RasGAP and the 64-kd protein are not sufficient mediators of PDGF's mitogenic signal.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
Article Abstract:
Mutations were introduced into the Stat1 gene in embryonic stem cells and in mice to study the activation of Stat1 in cell culture systems. Stat1(super-1-) showed no response to interferon but showed dependence on leukemia inhibitory factor for undifferentiated growth. Disruption of the gene had no effect on the physical characteristics and reproductive frequency of the animals. However, it reduced the animals' longevity and lowered their resistance to diseases, suggesting that Stat1 is essential for immune function.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology
Article Abstract:
Research points out that among the three functions of the suppressor of hairless (Su(H)) transducing transcription factor, involved in the Notch receptor signaling, a novel auto-activation function is Notch-independent, active throughout adult life and has a role in the mechanoreception.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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