Prolactin in man: A tale of two promoters
Article Abstract:
The insertion of two transposon-like DNA sequences in the human prolactin gene, which together function as an alternative promoter directing extrapituitary pituitary hormone prolactin (PRL) expression, is reported. It is supposed that the transposon insertion event has resulted in divergent expression of prolactin in primates, and in differential actions of pituitary versus extrapituitary prolactin in lactation versus pregnancy respectively.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2006
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Human genomic deletions mediated by recombination between Alu elements
Article Abstract:
The reference human and chimpanzee genomes are compared to determine the magnitude of the recombination between Alu elements in the human lineage since the human-chimpanzee divergence ~6 million years ago. It is found that Alu recombination-mediated genomic deletion has had a much higher impact than was inferred from previously identified isolated events and that it continues to contribute to the dynamic nature of the human genome.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
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Duplication and divergence in humans and chimpanzees
Article Abstract:
A comparison of segmental duplications in humans and chimpanzees is presented as they might help in understanding the origins of phenotypic difference between humans and their closest relatives. Comparisons revealed that a total of approximately 80 Mb of segmentally duplicated DNA in humans and 65 Mb in chimpanzees.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2006
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