Pseudocleavage is dispensable for polarity and development in C. elegans embryos
Article Abstract:
A mutation in the nematode Caenorhabditis elegans called nop-1 reveals that the pseudocleavage contractions and furrow are not necessary for the normal development of embryos. Embryos with the nop-1 mutation do not exhibit the anterior cortical contraction and the pseudocleavage furrow that were thought to be necessary for proper development. However, embryos produced by nop-1 mutant mothers are viable and fertile and have normal P granule localization.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
Article Abstract:
Molecular cloning of par-1, a gene necessary for asymmetric cell division in Caenorhabditis elegans revealed that par-1 encodes putative serine/threonine protein kinases that are distributed in the peripheral region of the zygote and distributed in the germline precursor cells before mitotic division. Mutations detected in the surface of the kinase domain indicates that kinase proteins are essential in par-1 function and in germline development.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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