RNA polymerase unveiled

Article Abstract:

Multisubunit RNA polymerases (RNAPs), which synthesize essentially all cellular RNA molecules, are discussed. Their core subunits are conserved all through evolution. A paradigm of interactions of core RNAP with nucleic acid and accessory factors driving its passage through a series of structurally distinct intermediates in a transcription cycle is based on decades of research. New models of the transcription elongation complex (TEC) have emerged and are largely consistent with the previous paradigm, suggesting that conversion to the TEC depends on closure of parts of RNAP around the RNA:DNA hybrid and the nascent RNA on its way out, a closed conformation.

United States, Biochemistry, Bacteria, Yeast, Yeast (Food product), Cellular control mechanisms, Cell regulation, Nucleic acids

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Tethering sigma(super 70) to RNA polymerase reveals high in vivo activity of sigma(super 70)-dependent pausing at promoter-distal locations

Article Abstract:

The effective concentration of sigma(super 70) in vivo, and the extent to which can regulate transcript is unknown. A study was conducted which reflected that tethering sigma(super 70) yields viable Escherichia coli strains in which alternative s-factor function is not impaired.

Escherichia coli, Genetic research

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Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in Drosophila

Article Abstract:

A study characterizing the role of Drosophila JIL-1 mediated H3 at Ser10 phosphorylation in transcription is presented by establishing that JIL-1 is required for the transcription of the majority of Drosophila genes.

Histones, Drosophila, Phosphorylation, Chemical properties

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