Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

Article Abstract:

The activator of the caspase cascade in vitro is investigated using caspase 9 (Casp9)-knockout mice. These mutant mice usually die at birth because of the failure of the cellular death machinery. The caspase cascade is an important component of cellular apoptosis without which cells continue to live and organ enlargement and malformation results. The addition of exogenous Casp9 induced the expression of the other caspase gene indicating that Casp9 is an upstream activator of the cascade.

Genetic aspects, Cell death, Enzymes, Enzyme regulation

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Membrane recruitment of the kinase cascade scaffold protein Ste5 by the G-beta-gamma complex underlies activation of the yeast pheromone response pathway

Article Abstract:

In the pheromone response path of the yeast, Saccharomyces cerevisiae, the B-beta-gamma complex activates downstream responses by a means that is not known, although some factors are known. The kinase cascade scaffold protein Ste5 is recruited to the membrane by the G-beta-gamma complex. That event is behind activation of the yeast pheromone response pathway.

Analysis, Observations, Saccharomyces, Protein kinases, Pheromones

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Requirement of JIP scaffold proteins for NMDA-mediated signal transduction

Article Abstract:

The article examines JIP scaffold proteins on mice for N-methyl-D-aspartic acid (NMDA) receptor function. The JIP scaffold proteins are important for the N-methyl-D-aspartic acid receptor function.

Science & research, Methyl aspartate, N-methyl-D-aspartate, Digital signal processor, Signal processing, Report

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