Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors
Article Abstract:
A model defining the role of the myocyte enhancer factor-2 (MEF-2) family of MADS box transcription factors in regulating the development of multiple muscle types is presented. It suggests that other regulatory factors restricted to the myogenic lineage of a muscle type interact with MEF-2 to control muscle gene expression. Application of the model to skeletal, cardiac and smooth muscle development show that MEF-2 function is highly conserved.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis
Article Abstract:
Each Drosophila larval hemisegment contains about 30 uniquely specified somatic muscles. They come from muscle founders that arise as distinct sibling pairs from muscle progenitor cell division. It can be seen that proteins Inscuteable and Numb are localized as cortical crescents on opposing sides of dividing progenitor cells. Both inscuteable and numb mediate asymmetric muscle progenitor cell divisions in Drosophila myogenesis.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis
Article Abstract:
Mef2, the myogenic regulatory gene, is a direct target for transcriptional activation by Twist, the bHLH transcription factor, during myogenesis in Drosophila. Twist controls Mef2 expression directly in adult somatic muscle precursor cells through a 175-bp enhancer 2245 bp upstream from the transcription start site. A novel transcription pathway has been defined for skeletal muscle development.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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