Regulation of the Neurospora circadian clock by an RNA helicase

Article Abstract:

The three components of the negative-feedback loop of the Neurospora circadian oscillator are Neurospora frequency (FRQ), white collar (WC)-1, and WC-2 and the study shows that all FRQ associates with FRH, an essential DEAD box-containing RNA helicase in Neurospora. The findings demonstrate that FRH is an essential component in the circadian negative-feedback loop and also reveals an unexpected role of an RNA helicase in regulating gene transcription.

United States, Influence, RNA

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Distinct roles for PP1 and PP2A in the Neurospora circadian clock

Article Abstract:

Phosphorylation of the Neurospora circadian clock protein FREQUENCY by several kinases promotes its degradation and is termed important for the function of the circadian feedlock loop. The lower FREQUENCY (FRQ) in a ppp-1 (catalytic subunit of PPI) mutant, resulting in its advanced phase and short period is highlighted.

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Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

Article Abstract:

The regulated phosphorylation of ribosomal protein (rp) S6 has attracted more attention since its discovery in 1974 but its physiological role has remained obscure. Viable and fertile knock-in mice are established whose rpS6 contains alanine substitutions at all five phosphorylatable serine residues.

Homeostasis, Ribosomal proteins

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