Starting at the beginning, middle, and end: translation initiation in eukaryotes
Article Abstract:
Eukaryotic cells follow a similar recruitment of ribosomes to mRNA pattern with prokaryotic cells but the enaction of vital features of the formation is distinct between them. Prokaryotic cells have the pattern of recruiting the ribosomal subunit to mRNA which is controlled by the basepairing between the 16S rRNA and the Shine-Dalgarno sequence to mRNA. On the other hand, eukaryotes' recruitment pattern of small ribosomal subunit to mRNA is instructed by protein-protein and protein-RNA interactions.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Cell cycle-dependent translation initiation: IRES elements prevail
Article Abstract:
Internal ribosome entry site (IRES) elements in cell cycle-dependent translation initiation are discussed in this minireview article. Until recently fewer than twelve IRESs had been found on cellular mRNAs, but now several other interesting IRESs are known. Recent work looking into how specific mRNA sequences overcome the general inhibition of translation that occurs in the G2/M phase of the cell cycle is covered.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Ribosome loading onto the mRNA cap is driven by conformational coupling between elF4G and elF4E
Article Abstract:
Results show that mRNA, the eukaryotic initiation factor 4G (elF4G), and elF4E exist as a stable mRNP, which mediates ribosomal loading during translation initiation in protein synthesis. The solution structure of the complex between yeast elf4E/cap and elF4G is presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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