Steroid hormone receptors: many actors in search of a plot

Article Abstract:

Steroid hormone receptors (SHRs) bind to DNA hormone response elements and directly interact with the transcription initiation complex to increase transcription. SHRs suppress transcription by sequestering transcription factors into inactive forms, or competing for the DNA-binding site or transcription initiation complex. Null mutations in the glucocorticoid receptors are lethal in mice. Null mutations in the sex steroid receptors cause defects in the development of the reproduction organs. SHRs are expressed during embryonic development and adult homeostasis.

Analysis, Mutation (Biology), Mutation, Steroid hormones, Steroid receptors

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New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?

Article Abstract:

Glucocorticoids (GCs) are hormones necessary for combating stress and the regulation of various metabolic functions. Its actions are mediated by nuclear receptors which bind to glucocorticoid response elements (GRE) of chromosomes. Recent investigations using mice with mutant glucocorticoid receptors have challenged the hypothesis that GRE binding of the glucocorticoid-receptor complex is responsible for the induction of lung maturation by GCs. The possible mechanism of action for this observed function is presented.

DNA binding proteins

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DNA binding of the glucocorticoid receptor is not essential for survival

Article Abstract:

Glucocorticoid receptors (GR) are genetic regulators able to modulate transcription either through direct DNA interaction or transrepression of other regulatory elements. The relative contributions of DNA interaction and transrepression on the gene regulation function of GR are investigated in mice unable to dimerize receptors which is a necessary step before the receptor can interact with DNA. Results reveal that DNA binding is not essential to genetic regulation by GR.

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