With the correct concept of mutation rate, cluster mutations can explain the overdispersed molecular clock

Article Abstract:

David J. Cutler is mistaken in stating that clustered mutations have no substantial impact on the overdispersed molecular clock. He argues that this is because substitution and mutation are two different things. However, his idea of mutation rate is conceptually flawed and biologically unrealistic. His use of the unique mutational event rate instead of mutation rate is in error. It is appropriate to apply the mutation rate, which is obtained by determining the number of members in a cluster, and not the mutational event rate, which considers each cluster as one.

Cutler, David J.

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Clusters of identical new mutations can not account for the "overdispersed" molecular clock

Article Abstract:

H. Huai and R.C. Woodruff made a serious error in their article 'Clusters of identical new mutations can account for the overdispersed molecular clock.' The mistakenly arrived at the conclusion because they erroneously equated the variance-to-mean ratio of one quantity with that of another. They have computed the variance-to-mean ratio for the number of mutations that have ever risen in a population and mistook this for the variance-to-mean ratio of the mutation rate. Their calculate value has no relation to the index of dispersion of the molecular clock.

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Clustered mutations have no effect on the overdispersed molecular clock: a response to Huai and Woodruff

Article Abstract:

H. Huai and R.C. Woodruff's article 'Clusters of identical new mutations can account for the overdispersed molecular clock,' contained some errors. They mistakenly obtained the finding that clustered mutations can have a substantial impact on the pattern of molecular evolution because they made the error of considering substition and mutation as similar. Huai and Woodruff's overestimation of the index of dispersion or the ratio of the variance in the number of substitutions to the mean number led to the false conclusion.

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