Structural and functional analysis of the mitotic rotamase pin1 suggests substrate recognition is phosphorylation dependent
Article Abstract:
The possibility of phosphorylation-mediated control of Pin1-substrate interactions in cell cycle regulation can be seen in the Pin1 preference of an acidic residue N-terminal to the isomerized proline bond due to interaction of the acidic side chain with a basic cluster. Based on the research, a catalytic mechanism which includes general acid-base and covalent catalysis during peptide bond is seen in the study of crystalographic structure, pH titration and mutagenesis of an active site cysteine. Such analysis shows what influences eukaryotic cell cycle.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans
Article Abstract:
The role of pairing centers (PCs), cis-acting sites required for accurate segregation of homologous chromosomes during meiosis in C. elegans is investigated. It is found that the sites play dual roles that contribute to proper segregation where chromosomes lacking PCs fail to synapse and also lack a synapsis-independent stabilization activity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Whence meiosis?
Article Abstract:
The aim of this minireview is to discuss sexual reproduction, meiosis. The authors reconstruct events affecting the sexual reproduction development in an ancient eukaryotic ancestor.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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- Abstracts: Structural basis for relief of autoinhibition of the DbI homology domain of proto-oncogene Vav by tyrosine phosphorylation
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