Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis
Article Abstract:
The expression of the gene encoding the beta(sub 1) integrin subunit in the suprabasal epidermal layers in mice causes a phenotype similar to human psoriasis. The mice show epidermal hyperproliferation, defective keratinocyte differentiation and skin inflammation. The phenotype is due to defective keratinocytes as inflammation is always associated with keratinocytes defects. Mice expressing the alpha(sub 5), beta(sub 1), or the alpha(sub 2)-beta(sub 1) or alpha(sub 5)-beta(sub 1) heterodimers show defects in the hair and whiskers and no fusion of the eyelids.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression
Article Abstract:
The separation of human epidermal stem cells from transit amplifying cells based on differences in integrin function and expression is reported. Transit amplifying cells have a lower capacity for self-renewal and a higher probability of undergoing terminal differentiation than epidermal stem cells. The results showed that keratinocytes with stem cell characteristics can be separated from cultured human epidermal cells based on the former's higher expression of beta-1 integrins and rapid adhesion to extracellular matrix proteins.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Stem cell patterning and fate in human epidermis
Article Abstract:
Experimental analysis of patterning of stem cells and transit-amplifying cells in human epidermis shows that expression of alpha3-beta1 and alpha2-beta1 integrins is high in the stem cells than in transit-amplifying cells and that this high level expression enables the identification of the stem cell position in the epidermis. Both cells do not display random distribution. The integrin-dull and integrin-bright cells display specific position as a function of the epidermal-dermal junction.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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