Synaptic transmission: a bidirectional and self-modifiable form of cell-cell communication
Article Abstract:
An overview of synaptic transmission focusing on the bidirectional nature of information transfer at synapses is presented. Modern understanding of neuronal signaling is derived largely from the ionic hypothesis developed in 1949 by Hodgekin, Huxley and Katz. Most of the current knowledge at the molecular level has elucidated much of the postsynaptic components of synaptic transmission. In contrast, progress in the understanding of presynaptic components has been slower. As the mechanisms of presynaptic transmission become clearer, a better understanding of behavior, learning and memory at the molecular level will also be achieved.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Spatial learning and memory: the beginning of a dream
Article Abstract:
Research on the neurobiology of learning focused on the synaptic plasticity and neuronal activity of the hippocampus. Analysis of nerve impulses indicated the relationship between hippocampal place fields and spatial learning and memory in rodents. The activation of specific neurons in the rodent hippocampus is also dependent on a given environment and situation due to the formation of a cognitive map by the hippocampus.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Synaptic structure and function: dynamic organization yields architectural precision
Article Abstract:
Recent evidence shows that the dynamic nature of synaptic structures enables them to undergo structural reorganization under some circumstances without altering their overall structural integrity. This plasticity influences transmission in chemical synapses in response to an action potential. These synapses send signals to receptors on axons to elicit specific responses.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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