Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition

Article Abstract:

Research has been conducted on the transcription factor phosphorylation. The DNA binding regulation of the Ets-1 transcription factor by phosphorylation is discussed.

Analysis, Phosphorylation, Genetic research

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TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

Article Abstract:

TEA DNA (TEAD)/ transcription enhancer factor (TEF) transcription factors have been found to utilize the activation domain of YAP65. Mammals express four highly conserved TEAD/TEF transcription factors that bind one DNA sequence. They have different jobs, however, in development. To identify mammalian proteins that modify TEAD-2 activity, a tagged-mouse TEAD-2 protein was expressed in mouse cells. TEAD-2 protein complexes were purified by affinity chromatography. This strategy shows the relative abundance of each protein in a complex assembled in vivo under native conditions and identifies all proteins that associate with the tagged protein, whether or not they bind independently or together with other proteins. YAP65 is a Src/Yes-associated protein in cytoplasm.

Physiological aspects, Cytogenetics, Lymphocytes

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Full and partial genome-wide assembly and disassembly of the yeast transcription machinery in response to heat shock

Article Abstract:

The genome-wide location of representative members of sequence-specific DNA-binding proteins, chromatin regulators, general transcription factors and elongation factors and their redistribution when Saccharomyces cerevisiae genome is reprogrammed by heat shock are examined. Assembly of active transcription complex is found to be coupled to eviction of H2A.Z nucleosome, and disassembly coupled to the return of nucleosome.

Science & research, Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Genetic aspects, Heat shock proteins, Brewer's yeast, Saccharomyces cerevisiae

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