Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
Article Abstract:
The janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway has been shown to be involved in many biological processes. JAK proteins are bound to cytokine receptors and signaling is triggered when cytokine binding induces receptor dimerization whereas STAT proteins are activated by tyrosine phosphorylation to form homodimers and heterodimers that activate cytokine-inducible genes. However, there is no information regarding the mechanism by which pathway specificity is manifested. An experiment on mice deficient in STAT1 is discussed to elucidate this mechanism.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Cyclooxygenase regulates angiogenesis induced by colon cancer cells
Article Abstract:
A study was conducted to determine on the role of cyclooxygenase on the neovascularization and cell migration. Endothelial and cancer cells were colcultured and the effect of the cyclooxygenase inhibitors on the endothelial tube formation was analyzed. Results revealed that cyclooxygenase regulates colon carcinoma-induced angiogenesis by modulating production of angiogenic factors by colon cancer cells and regulating angiogenesis in endothelial cells. Such findings yield important implications on the prevention of cancer.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
Article Abstract:
A study was conducted to examine the physiological features of mice that lacks the Janus kinase Jak1. One genetic factor that was cited for the birth defects and subsequent perinatal death of the animals was the failure of Jak1 cells to biologically respond to cytokines. The results indicated the major role played by the kinase in promoting the biologic responses caused by cytokine receptors.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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