The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
Article Abstract:
Results shpw that mutations in the mammalian Mst1 and Mst2 related hippo protein kinase cause enhanced tissue growth and reduced apoptosis as revealed by elevated levels of cell cycle regulator cyclin E and apoptosis inhibitor DIAP1. Data indicate that interaction between hippo encoded protein and serine/threonine kinase and salvador gene encoded protein regulate DIAP1 possibly by hippo protein-mediaed phosphorylation and degradation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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A pericellular collagenase directs the 3-dimensional development of white adipose tissue
Article Abstract:
The membrane-anchored metalloproteinase, Mt1-MMP, coordinates adipocyte differentiation in vivo. MT1-MMP acts as a 3-D-specific adipogenic factor that directs the dynamic adipocyte-ECM interactions critical to white adipose tissue development.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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