The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome
Article Abstract:
Research has been conducted on human multiprotein complex WINAC which interacts with vitamin D receptor via Williams syndrom transcription factor. Results demonstrate that WINAC dysfunction affects the Williams syndrome, and that the Williams syndrom therefore can be considered a chromatin-remodeling factor disease.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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Inflammation and sex steroid receptors: A motif for change
Article Abstract:
The reversal of the inhibitory effects of sex hormone receptor antagonists by the proinflammatory cytokine interleukin-1 beta (IL-1beta) is discussed. Proinflammatory signals target adaptor protein TAB2 and switches repressed steroid hormone receptors into transcriptional activators.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Nuclear receptors: a rendezvous for chromatin remodeling factors
Article Abstract:
This review examines the molecular mechanisms involved in the control of gene expression by the transcription factor, vitamin D receptor, of the nuclear receptors family. A novel ATP-dependent chromatin remodeling complex, WINAC, is implicated in the regulatory mechanisms.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
User Contributions:
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