The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival
Article Abstract:
The cytoplasmic Purkinje onconeural antigen cdr2 found to down-regulate c-Myc function by sequestering c-Myc in neuron cytoplasm is discussed. A study has shown that cdr2 interacts specifically with the helix-leucine zipper (HLZ) motif of c-Myc and that cdr2 is a cytoplasmic protein, an onconerual antigen, which has an HLZ motif as well. An immune response to cdr2, associated with tumor immunity and autoimmune cerebeller degeneration, is led to by expression of cdr2, normally expressed in cerebellar Purkinje neurons. Autoantibodies in PCD, paraneoplastic cerebellar degeneration, may contribute to Purkinje neuronal death. These findings have implications for tumor cell and neuronal cell survival.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
A cell-counting factor regulating structure size in Dictyostelium
Article Abstract:
A cell-counting factor that regulates Dictyostelium structure size is discussed. Developing cells of this simple eukaryote, which normally exists as a single cell that eats bacteria on soil and increases by fission, for large aggregation streams that separate into groups of cells numbering within a certain range each group of which runs into a fruiting body, but smlA cells oversecrete an unknown substance that makes aggregation streams break up into groups of a given size to form very small fruiting bodies, so the substances that is the counting factor was purified and found to act as a complex, one polypeptide of which is now named countin.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The yin and yang of P-TEFb regulation: Implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation
- Abstracts: Stable-carbon and nitrogen isotope ratios of songbird feathers grown in two terrestrial biomes: implications for evaluating trophic relationships and breeding origins
- Abstracts: A bioluminescence assay using Nitrosomonas europaea for rapid and sensitive detection of nitrification inhibitors
- Abstracts: The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Ga14. Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP-aluminum fluoride: insights into activator mechanochemical action
- Abstracts: Building better vasculature. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells