The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
Article Abstract:
Research shows that misfolded protein-induced stress is managed by the microtubule-associated deacetylase, HDAC6, which is a component of the aggresome. The HDAC6 binds both polyubiquinitated misfolded proteins and dynein motors and recruit misfolded proteins to dynein motors for transport to aggresomes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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Interleukin 20: discovery, receptor identification, and role in epidermal function
Article Abstract:
Bioinformatics analysis reveals the discovery of a novel interleukin 10 homolog, interleukin 20. The new cytokine causes neonatal lethality and aberrant epidermal differentiation. Recombinant interleukin 20 mediates signal transduction in keratocyte cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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ICEBERG: a novel inhibitor of interleukin-2beta generation
Article Abstract:
ICEBERG, a member of the death-domain-fold superfamily, has been found to be a novel inhibitor of interleukin-2beta generation. It may be part of a negative feedback loop, being induced by proinflammatory stimulae.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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