The highly immunogenic enolase and Hsp70p are adventitious Candida albicans cell wall proteins
Article Abstract:
The presence of cytosolic proteins such as enolase and heat-shock protein (Hsp70p) in the cell wall of Candida albicans was investigated using the SDS-PAGE, Western blot technique and indirect immunofluorescence. They are highly immunogenic which can help the fungus to evade the host defense mechanisms. The screened cDNA libraries gave several positive clones with polyclonal antibody preparations which encode enolase, Hsp70p and other proteins as detected with antibodies against yeast cells and mycelial walls.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1997
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A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans
Article Abstract:
The Candida albicans MKC1 gene encodes a mitogen-activated-protein (MAP) kinase. The physiological function of this MAP kinase in the pathogenic fungus C. albicans was characterized. MKC1 was also observed to play an important role in the biogenesis of cell wall. It has also a function in morphological transitions in C. albicans as evidenced by the disruption of pseudohyphal formation of mkc1delta/mkc1delta strains on Spider medium.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1998
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The Hsp90 pf Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C.albicans infections
Article Abstract:
Results show that Hsp90 of Candida albicans and the degraded form Hsp82 of Saccharomyces cerevisiae when expressed in the latter undergo similar breakdown pathway producing the same degradation products. The usefulness of this experimental approach to study the occurrence of such antigenic fragments during candidal infections is presented.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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