The homeodomain: a new face for the helix-turn-helix?
Article Abstract:
The presence of homeodomains (HD) across species boundaries suggest that these trasncriptional regulators have been conserved throughout evolution. However, despite its similar carboxy-terminal sequence with the helix-turn-helix (HTH) of prokaryotic regulatory proteins, HD interacts with deoxribonucleic acids distinctly, suggesting the presence of other residues to account for this observed difference. This has been identified to be amino acid 9 of the carboxy-terminal end, whose activity may be modified by regions other than the HTH.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
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Reversible histone modifications and the chromosome cell cycle
Article Abstract:
Phosphorylation of serine and threonine and the acetylation and ubiquitination of lysines occur in chromosomes entering the metaphase stage of cell division. These processes occur in the nitrogen and carbon terminal domains of histones, causing chromosome replication, transcription, condensation and change in charge densities. These chromosomal structural alterations are also believed to regulate cell cycle processes.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
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The management of DNA double-strand breaks in mitotic [G.sub.2], and in mammalian meiosis viewed from a mitotic [G.sub.2] perspective
Article Abstract:
The management of the DNA double-strand breaks (DSBs) in the [G.sub.2] phase of the mitotic cycle of any DNA-bearing organism, especially mammals is explained. The study shows that a process called homologous recombinational pair (HRR) is used widely for repairing the DSBs.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2007
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